Pulse oximetry

Amal Jubran
Introduction
Continuous monitoring of arterial blood saturation using pulse oximetry has become the standard of care in the ICU. With the proliferation of pulse oximeters, episodic hypoxemia is detected much more commonly than previously suspected. By alerting the clinician to the presence of hypoxemia, pulse oximeters can lead to a more
rapid treatment of serious hypoxemia and possibly avoid serious complication. Moreover, pulse oximetry can reduce arterial blood gas analysis and potentially decreasehealth care costs [1].
Principles of pulse oximetry
Pulse oximeters determine oxygen (O2) saturation by measuring light absorption of arterial blood at two specific wavelengths, 660 nm (red) and 940 nm (infrared) [2]. The ratio of absorbencies at the wavelengths is then calibrated empirically against direct measurements of arterial blood oxygen saturation (SaO2), and the resulting calibration curve is used to generate the pulse oximeter’s estimate of arterial saturation (SpO2). In addition to the digital read-out of O2 saturation, most pulse oximeters display a plethysmographic waveform, which can help clinicians distinguish an artifactual signal from the true
signal (Fig. 1). The accuracy of commercially available oximeters in critically ill patients has been validated in several studies [3]. Compared with the measurement standard (multiwavelength CO oximeter), pulse oximeters have a mean difference (bias) of less than 1% and a standard deviation (precision) of less than 2% when SaO2 is 90% or above [4]. While pulse oximetry is accurate in reflecting onepoint measurements of SaO2, it does not reliably predict changes in SaO2 [4]. Moreover, the accuracy of pulse oximeters deteriorates when SaO2 falls to 80% or less. In critically ill patients, poor agreement between the oximeter and a CO oximeter has been observed, with bias the Fig. 1Common pulsatile signals on a pulse oximeter. Top panel Normal signal showing the sharp waveform with a clear dicrotic notch. Second panel Pulsatile signal during low perfusion showing a typical sine wave. Third panel Pulsatile signal with superimposed noise artifact giving a jagged appearance. Lowest panel Pulsatile signal during motion artifact showing an erratic waveform. (From [1])ranging from 12% to 18%, and oximetry tends systematically to underestimate SaO2 when it is 80% or less.
Limitations of pulse oximetry
Oximeters have a number of limitations which may lead to inaccurate readings [1]; these are presented below.
Physiological limitations
Oxyhemoglobin dissociation curve
Pulse oximeters measure SaO2, which is physiologically related to arterial oxygen tension (PaO2) according to the oxyhemoglobin dissociation curve. Because the dissociation curve has a sigmoid shape, oximetry is relatively insensitive in detecting the development of hypoxemia in patients with high baseline levels of PaO2.
Limitation in the signal processing
Ambient light
Although pulse oximeters correct for ambient light, falsely low SpO2 readings have been reported with fluorescent and xenon arc surgical lamps. Wrapping the probe with an opaque shield can minimize this effect.
Low perfusion
Pulse oximetry depends on satisfactory arterial perfusion of the skin, and thus low cardiac output, vasoconstriction, or hypothermia can make it difficult for a sensor to distinguish the true signal from background noise. In cardiac surgery patients experiencing hypothermia and poor perfusion, only 2 of 20 oximeters (Criticare CSI 503, Datex Satlite) provide measurements within €4% of the CO oximeter value.
Motion artifact
The occurrence of motion artifacts continues to be a significant source of error and false alarms. In 235 surgical patients managed in the ICU, 67% of pulse oximeter
alarms were false [5]. An innovative technological approach, termed Masimo signal extraction technology, was introduced to extract the true signal from artifact due
to noise and low perfusion. When tested in 50 postoperative patients, the pulse oximeter’s alarm frequency was decreased twofold with the new system vs. a conventional
oximeter. When tested under conditions of low perfusion and motion, the ability to track changes in SpO2 and reduce nuisance alarms was improved with this
technology [3].
Interference from substances
Dyshemoglobins
Pulse oximeters employ only two wavelengths of light and thus can distinguish only two substances, oxyhemoglobin and reduced hemoglobin. Accordingly, elevated carboxyhemoglobin and methemoglobin levels can cause inaccurate oximetry readings[1].
Intravenous dyes
Intravenous dyes such as methylene blue, indocyanine green, and indigo carmine can cause falsely low SpO2 readings, an effect that persists for up to 20 min.
Skin pigmentation and other pigments
Inaccurate oximetry readings have been observed in pigmented patients. In critically ill patients, a bias of more than 4% has been observed to occur more frequently in black (27%) than in white patients (11%). Nail polish, if
blue, green, or black, causes inaccurate SpO2 readings; however, mounting the oximeter probe sideways alleviates the problem with nail polish. Acrylic nails do not
interfere with readings.
Limited knowledge of technique
Many users have only a limited understanding of pulse oximetry. One survey revealed that 30% of physicians
and 93% of nurses thought that the oximeter measured PaO2. A more recent audit demonstrated that less than 50% of nurses and physicians were able to identify that motion artifact, arrhythmias, and nail polish can affect the accuracy of pulse oximeter [6].
Clinical applications
Detection of hypoxemia
With the introduction of pulse oximetry hypoxemia (defined as an SpO2 value less than 90%) is detected more often in critically ill patients. Moreover, myocardial ischemia (defined as angina or ST segment depression) in postoperative patients is less common in patients monitored with pulse oximetry than those without oximetry [7].
Assessing pulmonary gas exchange
Pulse oximeters measure SaO2, which is physiologically related to PaO2. In critically ill patients receiving mechanical ventilation, changes in SpO2 may not accurately
reflect changes in PaO2 and may in fact be in an opposite direction to the change in PO2. Decisions in therapy made
on the basis of SpO2 alone can also differ from those based on PO2. Accordingly, caution is required when making decisions in critically ill patients based solely on
pulse oximetry. While pulse oximetry is a suitable way of measuring arterial oxygenation, it does not assess ventilation. Indeed, measurements of SpO2 have been shown to be inaccurate in assessing abnormal pulmonary gas exchange, defined as an elevated alveolar-arterial O2 difference
Titration of fractional inspired oxygen concentration
Pulse oximetry can assist with titration of fractional inspired oxygen concentration (FIO2) in ventilator-dependent patients, although the appropriate SpO2 target depends
on a patient’s pigmentation. In white patients, an SpO2 target value of 92% predicts a satisfactory level of oxygenation, whereas black patients required an SpO2
target of 95%. In patients with severe acute respiratory distress syndrome, an SpO2 target of 88–90% is acceptable in order to minimize oxygen toxicity.
Blood pressure measurements
In pulse oximeters that display a pulsatile waveform, systolic blood pressure can be measured by noting the reappearance of the pulsatile waveform during cuff deflation
or the waveform disappearance during slow cuff inflation (Fig. 1). In healthy volunteers, good agreement (i.e., bias <1.0>